AUTHOR=Han Yibing , Qiu Wen , Zhang Yu , Hua Mengmeng , Liu Shaohua , Dong Zuoqing TITLE=From prenatal diagnosis to surgical treatment: two case reports of congenital granular cell epulis JOURNAL=Pathology and Oncology Research VOLUME=30 YEAR=2024 URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2024.1611834 DOI=10.3389/pore.2024.1611834 ISSN=1532-2807 ABSTRACT=

Herein, we detail a multidisciplinary approach and sequential treatment for two infants with congenital granular cell epulis (CGCE). Ultrasonic examinations at 34 weeks of gestation revealed prominent oral masses in both fetuses. To devise a carefully considered treatment strategy, a comprehensive multidisciplinary consultation including oral and maxillofacial surgeons, pediatricians, obstetricians, and anesthesiologists was convened. Following cesarean sections, the lesions were successfully removed, measuring approximately 30 × 15 mm and 30 × 20 mm in size, respectively. Immunohistochemical analysis showed that vimentin was positive, S-100 protein was negative, and NSE protein and CD68 protein were negative. These findings underscore the importance of prenatal diagnosis of congenital granular cell epulis for the effective management of these rare benign conditions.