AUTHOR=Han Zesen , Yang Fujun , Wang Fang , Zheng Huayu , Chen Xiujian , Meng Hongyu , Li Fenglei 

TITLE=Advances in combined neuroendocrine carcinoma of lung cancer

JOURNAL=Pathology and Oncology Research

VOLUME=30

YEAR=2024

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2024.1611693

DOI=10.3389/pore.2024.1611693

ISSN=1532-2807

ABSTRACT=<p>Lung cancer incidence and mortality rates are increasing worldwide, posing a significant public health challenge and an immense burden to affected families. Lung cancer encompasses distinct subtypes, namely, non-small-cell lung cancer (NSCLC) and small-cell lung cancer (SCLC). In clinical investigations, researchers have observed that neuroendocrine tumors can be classified into four types: typical carcinoid, atypical carcinoid, small-cell carcinoma, and large-cell neuroendocrine carcinoma based on their unique features. However, there exist combined forms of neuroendocrine cancer. This study focuses specifically on combined pulmonary carcinomas with a neuroendocrine component. In this comprehensive review article, the authors provide an overview of combined lung cancers and present two pathological images to visually depict these distinctive subtypes.</p>