AUTHOR=Rubovszky Gábor , Kocsis Judit , Boér Katalin , Chilingirova Nataliya , Dank Magdolna , Kahán Zsuzsanna , Kaidarova Dilyara , Kövér Erika , Krakovská Bibiana Vertáková , Máhr Károly , Mriňáková Bela , Pikó Béla , Božović-Spasojević Ivana , Horváth Zsolt TITLE=Systemic Treatment of Breast Cancer. 1st Central-Eastern European Professional Consensus Statement on Breast Cancer JOURNAL=Pathology and Oncology Research VOLUME=28 YEAR=2022 URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2022.1610383 DOI=10.3389/pore.2022.1610383 ISSN=1532-2807 ABSTRACT=

This text is based on the recommendations accepted by the 4th Hungarian Consensus Conference on Breast Cancer, modified based on the international consultation and conference within the frames of the Central-Eastern European Academy of Oncology. The professional guideline primarily reflects the resolutions and recommendations of the current ESMO, NCCN and ABC5, as well as that of the St. Gallen Consensus Conference statements. The recommendations cover classical prognostic factors and certain multigene tests, which play an important role in therapeutic decision-making. From a didactic point of view, the text first addresses early and then locally advanced breast cancer, followed by locoregionally recurrent and metastatic breast cancer. Within these, we discuss each group according to the available therapeutic options. At the end of the recommendations, we summarize the criteria for treatment in certain rare clinical situations.