AUTHOR=Nagy Zsófia F. , Ferenczi Kata , Istenes Ildikó , Eid Hanna , Bödör Csaba , Timár Botond , Demeter Judit 

TITLE=Case Report: Development of Diffuse Large B Cell Lymphoma a Long Time After Hairy Cell Leukemia

JOURNAL=Pathology and Oncology Research

VOLUME=28

YEAR=2022

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2022.1610338

DOI=10.3389/pore.2022.1610338

ISSN=1532-2807

ABSTRACT=<p>Hairy cell leukaemia (HCL) is a rare B cell malignancy with an indolent course leading to pancytopaenia due to bone marrow infiltration. It has been proposed that HCL patients are at risk of developing a secondary malignancy, with a marked likelihood of the development of other hematologic malignancies including Hodgkin lymphoma and high-grade non-Hodgkin lymphomas. Here, we present the case of two patients who developed diffuse large B cell lymphoma after a long course of hairy cell leukaemia. In the case of the female patient, we report on the occurrence of a third malignant disease, which is very uncommon. With our case descriptions we contribute to the very small number of similar cases reported.</p>