AUTHOR=Jiang Yu , Zhang Zhiqiang , Wang Xian , Feng Zhenzhong , Hong Bo , Yu Dexin , Wang Yi 

TITLE=A Novel Prognostic Factor TIPE2 in Bladder Cancer

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 28 - 2022

YEAR=2022

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2022.1610282

DOI=10.3389/pore.2022.1610282

ISSN=1532-2807

ABSTRACT=Objective We sought to identify tumor necrosis factor (TNF)-alpha-induced protein 8-like 2 (TIPE2/TNFAIP8L2) expression in bladder cancer and its relationship to clinicopathological findings and prognosis. Methods Immunohistochemical (IHC) staining for TIPE2 was performed on 110 archived radical cystectomy specimens. Ten high-power fields were randomly selected from each specimen to observe and record the percentage of immunoreactive cells of TIPE2 in tumor cells (grade 0-4) and the corresponding immunostaining intensity (grade 0-3). The expression score of TIPE2 was obtained by multiplying the results of the above two scores, which ranged from 0 to 12 points. The cut-off point of the sum of the scores were defined as follows: 0 ~ 3 scores were defined as negative expression (-); > 3 scores were classified as positive expression, < 7, low expression, ≥7, high expression. Results In 110 cases, TIPE2 was stained in various degrees in bladder cancer tissues. 4.5% (5/110) showed negative expression, 40.9% (45/110) showed low expression, and 54.5% (60/110) showed high expression. TIPE2 expression was negatively correlated with lymph node metastasis (P = 0.004) and disease progression (P = 0.021). Survival curves were plotted to show that patients with high TIPE2 expression had a progression-free survival curve above those with negative/low TIPE2 expression (P=0.027). In Cox proportional risk regression analysis, TIPE2 was a protective factor for progression-free survival in bladder urothelial carcinoma (P = 0.031). Conclusion TIPE2 may be a new biomarker to predict the disease progression and prognosis of patients with urothelial carcinoma of the bladder.