AUTHOR=Popov Alexey , Mandys Vaclav 

TITLE=Senescence-Associated miRNAs and Their Role in Pancreatic Cancer

JOURNAL=Pathology and Oncology Research

VOLUME=Volume 28 - 2022

YEAR=2022

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2022.1610156

DOI=10.3389/pore.2022.1610156

ISSN=1532-2807

ABSTRACT=Replicative senescence is irreversible cell proliferation arrest for somatic cells which can be circumvented in cancers. Cellular senescence is a process, which may act in a two opposite directions. On the first look, this is a natural mechanism of somatic cells protection against unlimited proliferation and malignant transformation. But, aberrant persistent senescent cells secretion can stimulate inflammation and adjacent cells proliferation what may promote malignance and stimulate cancerogenesis. Main genes controlling the senescence pathways are also well known as tumor suppressors. Almost 140 senescence-associated genes regulate both cellular senescence and cancer pathways. Two thirds of these genes (64%) undergo microRNAs regulation. Senescence-associated miRNAs can stimulate cancer progression or act as a tumor suppressors. Here we review the role playing by senescence-associated miRNAs in development, diagnostics and treatment of pancreatic cancer.