AUTHOR=Zhang Chuan-Long , Fan Kui , Gao Meng-Qi , Pang Bo 

TITLE=Prognostic Value of Glasgow Prognostic Score in Non-small Cell Lung Cancer: A Systematic Review and Meta-Analysis

JOURNAL=Pathology and Oncology Research

VOLUME=28

YEAR=2022

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2022.1610109

DOI=10.3389/pore.2022.1610109

ISSN=1532-2807

ABSTRACT=<p><bold>Background:</bold> Systemic inflammation is a key factor in tumor growth. The Glasgow Prognostic Score (GPS) has a certain value in predicting the prognosis of lung cancer. However, these results still do not have a unified direction.</p><p><bold>Methods:</bold> A systematic review and meta-analysis were performed to investigate the relationship between GPS and the prognosis of patients with non-small cell lung cancer (NSCLC). We set patients as follows: GPS = 0 vs. GPS = 1 or 2, GPS = 0 vs. GPS = 1, GPS = 0 vs. GPS = 2. We collected the hazard ratio (HR) and the 95% confidence interval (CI).</p><p><bold>Results:</bold> A total of 21 studies were included, involving 7333 patients. We observed a significant correlation with GPS and poor OS in NSCLC patients (HR<sub>GPS=0 vs. GPS=1 or 2</sub> = 1.62, 95% CI: 1.27–2.07, <italic>p</italic> ≤ .001; HR<sub>GPS=0 vs GPS=1</sub> = 2.14, 95% CI:1.31–3.49, <italic>p</italic> ≤ .001; HR<sub>GPS=0 vs. GPS=2</sub> = 2.64, 95% CI: 1.45–4.82, <italic>p</italic> ≤ .001). Moreover, we made a subgroup analysis of surgery and stage. The results showed that when divided into GPS = 0 group and GPS = 1 or 2 group, the effect of high GPS on OS was more obvious in surgery (HR = 1.79, 95% CI: 1.08–2.97, <italic>p</italic> = .024). When GPS was divided into two groups (GPS = 0 and GPS = 1 or 2), the III-IV stage, higher GPS is associated with poor OS (HR = 1.73, 95% CI: 1.43–2.09, <italic>p</italic> ≤ .001). In the comparison of GPS = 0 and GPS = 1 group (HR = 1.56, 95% CI: 1.05–2.31, <italic>p</italic> = .026) and the grouping of GPS = 0 and GPS = 2(HR = 2.23, 95% CI: 1.17–4.26, <italic>p</italic> = .015), we came to the same conclusion.</p><p><bold>Conclusion:</bold> For patients with NSCLC, higher GPS is associated with poor prognosis, and GPS may be a reliable prognostic indicator. The decrease of GPS after pretreatment may be an effective way to improve the prognosis of NSCLC.</p>