AUTHOR=Yang AI , Li Min , Fang Mingzhi
TITLE=The Research Progress of Direct KRAS G12C Mutation Inhibitors
JOURNAL=Pathology and Oncology Research
VOLUME=27
YEAR=2021
URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2021.631095
DOI=10.3389/pore.2021.631095
ISSN=1532-2807
ABSTRACT=
Abstract: KRAS mutations have long been considered undruggable. However, a series of direct KRAS mutation inhibitors have been developed since the switch II pocket was discovered recently. This review will summarize progress in the development of direct KRAS G12C mutation inhibitors, current relevant drugs under study and challenges that need to be considered in future research.