AUTHOR=Yang AI , Li Min , Fang Mingzhi TITLE=The Research Progress of Direct KRAS G12C Mutation Inhibitors JOURNAL=Pathology and Oncology Research VOLUME=27 YEAR=2021 URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2021.631095 DOI=10.3389/pore.2021.631095 ISSN=1532-2807 ABSTRACT=

Abstract: KRAS mutations have long been considered undruggable. However, a series of direct KRAS mutation inhibitors have been developed since the switch II pocket was discovered recently. This review will summarize progress in the development of direct KRAS G12C mutation inhibitors, current relevant drugs under study and challenges that need to be considered in future research.