AUTHOR=Kong Jinyu , Yuan Xiang , Wang Jian , Liu Yiwen , Sun Wei , Gu Bianli , Lan Zijun , Gao Shegan 

TITLE=Frequencies of Porphyromonas gingivalis Detection in Oral-Digestive Tract Tumors

JOURNAL=Pathology and Oncology Research

VOLUME=27

YEAR=2021

URL=https://www.por-journal.com/journals/pathology-and-oncology-research/articles/10.3389/pore.2021.628942

DOI=10.3389/pore.2021.628942

ISSN=1532-2807

ABSTRACT=<p>Mounting evidence suggests a causal relationship between specific bacterial infections and the development of certain malignancies. In this study, we examined the presence of <italic>Porphyromonas gingivalis</italic> (<italic>P. gingivalis</italic>) in oral-digestive tract tumors by immunohistochemistry (IHC) and PCR and analyzed the correlation between <italic>P. gingivalis</italic> detection and clinicopathological characteristics and prognosis of oral and esophageal carcinoma. The IHC results showed that the positive rates of <italic>P. gingivalis</italic> were 60.00, 46.00, 20.00, 6.67, and 2.86% in oral, esophagus, cardiac, stomach, and colorectal cancer tissues, respectively. Likewise, PCR results showed rates of 56.00, 42.00, 16.67, 3.33, and 2.86%, respectively. The two methods were consistent, and the <italic>kappa</italic> value was 0.806, <italic>P</italic> &lt; 0.001. In addition, <italic>P. gingivalis</italic> expression was significantly correlated with lymph node metastasis and the clinical stages of oral and esophageal cancer (<italic>P</italic> &lt; 0.05). The overall survival rate of the <italic>P. gingivalis</italic> undetected group (86, 50%) was significantly higher than that of the <italic>P. gingivalis</italic> detected group (57, 14%) for oral and esophageal cancer, respectively. In conclusion, the detection rate of <italic>P. gingivalis</italic> showed a decreasing trend in oral-digestive tract tumors. Detection with <italic>P. gingivalis</italic> was associated with poor prognosis for oral and esophageal cancer.</p>